Prostate cancer is the one of the most common cancer in men. Early detection and intervention remain key to best clinical outcome. Prostate cancer may cause no signs or symptoms in its early stages. More advanced stages may cause signs and symptoms such as trouble urinating, incontinence, decreased force in the stream of urine, blood in the urine or in the semen, bone pain, weight loss without trying and erectile dysfunction. Prostate screening is done in the office with a digital rectal examination (DRE) and a blood test called Prostate Specific Antigen (PSA). If prostate cancer screening detects an abnormality, further tests, such as an ultrasound or MRI or a prostate biopsy, may be necessary for the diagnosis.