SoHo Men's Health — Doctor-Led IV Therapy · NYC
NAD+, NR
& NMN Therapy
Three names for the same cellular currency — but they are not the same treatment. Dr. Kerem Bortecen breaks down NAD+, NR, and NMN so you can choose the option that actually fits your goals, your schedule, and your tolerance.
The Molecule
NAD+, NR & NMN — What's Actually the Difference?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell of the body, essential for converting food into cellular energy, repairing DNA, and regulating the enzymes that govern aging. NAD+ levels decline steadily from your late 20s onward — accelerated by stress, poor sleep, and alcohol.
NR (Nicotinamide Riboside) and NMN (Nicotinamide Mononucleotide) are not NAD+ itself — they are precursors your body converts into NAD+. NR converts to NMN, which converts to NAD+ (NR → NMN → NAD+). NMN sits one step closer to NAD+ in that chain.
At SoHo Men's Health, Dr. Kerem Bortecen offers all three as IV therapy or injection, and will most often recommend Niagen® NR as the preferred starting point — the best-studied precursor in human trials, with rapid uptake and the lowest rate of reported side effects of the three.
Our Space
A Private IV Room —
Bring a Friend or Partner
SoHo Men's Health is a spacious, upscale clinic with multiple private treatment rooms — including a dedicated IV suite built for comfort. Settle into a reclining chair, relax, and let your infusion run at an unhurried, physician-monitored pace.
Coming in with your partner, spouse, or a friend? You can receive your NAD+, NR, NMN, or iron IV side by side in the same room — turning your session into shared time rather than solo downtime.
Watch & Learn
NAD+, NR & NMN,
Explained
Still deciding between an IV and an injection — or which molecule is right for you? Dr. Bortecen breaks down how NAD+ and its precursors NR and NMN actually work inside your cells, and how doctor-led IV therapy at SoHo Men's Health puts them to use.
Why Raise NAD+
What Raising Your NAD+ Levels
Can Do For You
Cellular Energy Production
NAD+ is a core coenzyme in the Krebs cycle and mitochondrial ATP production — the pathway your cells use to convert food into usable energy. Restoring NAD+ supports the machinery behind sustained energy.
DNA Repair Support
NAD+ is a required substrate for the enzymes (sirtuins and PARPs) that detect and repair damaged DNA — a process that becomes less efficient as NAD+ levels decline with age.
Cognitive Function & Focus
The brain has high energy demands and is especially sensitive to oxidative stress. Patients on NAD+ precursor protocols at SoHo Men's Health commonly report sharper focus and reduced brain fog.
Metabolic & Detox Support
NAD+ drives the GSH enzyme system, a key antioxidant and detoxification pathway that neutralizes free radicals and supports overall metabolic health.
Physical Performance & Recovery
Because NAD+ underpins mitochondrial energy output, replenishing it is associated with improved stamina, workout recovery, and reduced fatigue — a common goal among SoHo Men's Health patients.
Zero Downtime
Whether you choose an IV drip or a quick injection, there's no recovery period. Walk in, get treated, walk out — straight back to your day.
Side By Side
NAD+ vs. NR vs. NMN
All three raise NAD+ levels — but they get there differently, feel different in the body, and suit different patients. Here's how Dr. Bortecen breaks it down.
| NAD+ | NR (Niagen®) Recommended |
NMN | |
|---|---|---|---|
| What It Is | The active, oxidized coenzyme itself | A precursor — converts to NMN, then NAD+ | A precursor — one step closer to NAD+ than NR |
| Delivery at SMH | IV drip (slow, monitored infusion) | IV drip (slow, monitored infusion) | IV drip (slow, monitored infusion) |
| Session Time | 30 min – 3 hrs (varies by bag size) | 30 min – 3 hrs (varies by bag size) | 30 min – 3 hrs (varies by bag size) |
| Common Reactions | Flushing, chest tightness, nausea, cramping — especially if infused too quickly | Mild warmth at most; side effects are rare and infrequently reported | Generally well tolerated; some report mild flushing with IV delivery |
| Human Trial Data | Extensive — decades of use in IV form | Well studied in human clinical trials as a patented, FDA safety-notified ingredient | Growing evidence; a 2023 trial showed doses up to 900 mg/day raised blood NAD+ over 60 days with no adverse effects reported |
| Best For | Patients who want the most immediate, direct NAD+ boost via infusion | Patients who want consistent, well-tolerated NAD+ support from the best-studied precursor | Patients who want a precursor that sits one step closer to NAD+ than NR |
Individual response varies. Dr. Bortecen reviews your health history and goals at consultation to confirm the right option and dose for you.
Make The Right Call
Which Option Is Best For You?
There's no single "best" NAD+ therapy for every patient — only the one that best fits your goals, schedule, and tolerance. Here's how Dr. Bortecen typically guides the conversation.
- You want the most direct NAD+ boost available
- You have time for a longer infusion — 30 minutes to 3 hours depending on bag size
- You're comfortable with a slower drip to manage flushing or cramping
- You want a one-time "reset" rather than a recurring routine
- You want the best-studied precursor with the lowest reported reaction rate
- You'd rather be in and out in under 10 minutes
- You want a sustainable weekly or biweekly routine, not a one-off
- You've had flushing or discomfort with direct NAD+ before
- You want a precursor that converts more directly to NAD+ than NR
- You're comfortable with an IV or injection format
- You're building a longevity-focused, research-informed protocol
- You want a middle ground between NR's tolerability and NAD+'s directness
The Add-On Peptide
What Is MOTS-c,
and Why Combine It?
MOTS-c is a mitochondrial-derived peptide — encoded not in your nuclear DNA but in the DNA of your mitochondria themselves. First identified in 2015, it's produced naturally in response to exercise and physical stress, and its levels decline with age, alongside NAD+.
- Activates the AMPK pathway, a central regulator of cellular energy balance
- Supports healthy glucose uptake and metabolic function in skeletal muscle
- Research links MOTS-c to improved insulin sensitivity and reduced age-related decline in physical function
- Complements NAD+ precursor therapy — MOTS-c signals metabolic regulation while NAD+ fuels the cellular energy pathways it regulates
At SoHo Men's Health, Dr. Bortecen offers MOTS-c as an add-on to any NAD+, NR, or NMN protocol for patients focused on metabolic health, exercise recovery, and longevity. Research on MOTS-c is still emerging, and it is offered as part of a broader wellness conversation with Dr. Bortecen — not as a substitute for medical treatment of diagnosed conditions.
Beyond NAD+
Iron Infusion at
SoHo Men's Health
Low iron is one of the most common — and most missed — causes of fatigue, poor recovery, brain fog, and hair thinning in men. When oral iron isn't enough or isn't tolerated, a doctor-led iron IV infusion restores your stores directly, without the stomach upset of pills.
As with every IV at SoHo Men's Health, your iron infusion is administered by board-certified Dr. Kerem Bortecen — dosed to your actual bloodwork, not a one-size-fits-all bag.
- Direct IV deliveryBypasses the gut for full, reliable absorption
- Dosed to your ferritinBloodwork drawn and reviewed before infusing
- Monitored, physician-administeredGiven at a controlled rate by Dr. Bortecen
- Targets real fatigueFor diagnosed iron deficiency and low ferritin
CJC / Ipamorelin / Tesamorelin can quietly drop your iron.
Raising IGF-1 accelerates red blood cell production, which pulls iron out of storage — so growth-hormone-secretagogue patients frequently develop low ferritin without realizing it. If you're running a CJC-1295, Ipamorelin, or Tesamorelin protocol, get your ferritin checked at SoHo Men's Health before it starts costing you energy and recovery.
Your Provider
Why Choose Dr. Kerem Bortecen for Your NAD+ Protocol?
Not every clinic offering NAD+ therapy is a medical practice. At SoHo Men's Health, every NAD+, NR, NMN, and MOTS-c protocol is designed and personally overseen by board-certified Dr. Kerem Bortecen — with a real medical evaluation behind every recommendation.
Dr. Bortecen takes a conservative, evidence-first approach: matching the option, dose, and delivery route to your actual health history rather than defaulting to whatever is trending.
"I default most patients to NR, not NAD+ IV, for one simple reason — it does the same job with a fraction of the reaction risk. I'd rather my patients feel nothing but the benefit."— Dr. Kerem Bortecen, Board-Certified Physician · Founder, SoHo Men's Health
Our IV & Injection Prices
NAD+, NR and NMN are all offered as a quick injection or a full IV drip — every option administered by board-certified Dr. Kerem Bortecen.
- NAD+ injection
- NR (Niagen®) injection
- NMN injection
- Flat $80 for all three
- Ideal for a weekly routine
- NAD+, NR or NMN IV drip
- Starts at $450 — price varies by bag size
- Monitored, titrated drip rate
- MOTS-c peptide add-on available
- Best for a deeper cellular reset
- For diagnosed low iron / ferritin
- Especially for CJC / Ipamorelin / Tesamorelin patients
- Ferritin bloodwork on site
- Dosed to your labs — priced at consultation
Not sure whether an injection or an IV fits your goals? Ask at your consultation →
SoHo Men's Health — NYC
Ready to Find Your
Right NAD+ Protocol?
Schedule your private consultation with board-certified Dr. Kerem Bortecen at SoHo Men's Health. Together you'll choose between NAD+, NR, NMN, and MOTS-c — no guesswork, no upsell, just the right fit for your goals.
Book Your ConsultationFrequently Asked Questions